The Gabrielle Rich Leukemia Research Foundation was brought to life after Denise and Marc Rich's second daughter died from complications of leukemia treatments at the age of twenty-seven in 1996. Gabrielle Rich was a talented young woman, with degrees in philosophy and the performing arts from Oxford and New York University. In 1996, Gabrielle succumbed to the side effects of treatment. It was her wish that a leukemia foundation be created.

The Gabrielle Rich Leukemia Research Foundation was closed in 2009 for administrative reasons and its activities were transferred to the Marc Rich Foundation. Together, these two Foundations have provided over $9 million in research grants and care support to institutions and medical centers in Europe, the United States, Israel, Spain and Italy.